by Darren ng | Aug 3, 2026 | Supplements
Short answer: A shelf supplement is a fixed dose in a fixed combination, formulated for a population average before anyone knew a single one of your patient’s numbers. It cannot be titrated to a ferritin result, cannot be adjusted when you retest, and cannot...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Resveratrol is a plant polyphenol — a stilbene concentrated in grape skins and Japanese knotweed — best known in the longevity field as a sirtuin activator studied alongside the NAD+ pathway. Its practical problem is absorption: although the gut takes up...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Quercetin is one of the clearest examples in the supplement world of a promising molecule held back by poor delivery. It is a flavonoid that dissolves badly in water, is heavily metabolised in the gut wall and liver within minutes of being absorbed, and...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Curcumin is the textbook example of a good molecule with a bad delivery profile. It is strongly fat-soluble and almost insoluble in water, it is metabolised and cleared quickly once it does get in, and the result is that most of a standard oral dose...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Vitamin C has an absorption ceiling that most prescribing conversations ignore. Uptake from the gut runs through a saturable sodium-dependent transporter (SVCT1), so once a patient is at steady state, plain oral doses above roughly 500 mg a day are...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Inositol — most often the pairing of myo-inositol and D-chiro-inositol — is one of the most commonly discussed supplements in polycystic ovary syndrome (PCOS) and insulin-resistance care, usually cited in a 40:1 myo-to-D-chiro ratio at around 4 g of...
