by Darren ng | Aug 3, 2026 | Supplements
Short answer: Quercetin is one of the clearest examples in the supplement world of a promising molecule held back by poor delivery. It is a flavonoid that dissolves badly in water, is heavily metabolised in the gut wall and liver within minutes of being absorbed, and...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Curcumin is the textbook example of a good molecule with a bad delivery profile. It is strongly fat-soluble and almost insoluble in water, it is metabolised and cleared quickly once it does get in, and the result is that most of a standard oral dose...
by Darren ng | Aug 3, 2026 | Compounding Pharmacy
Short answer: In a topical preparation, the base is not inert packaging around the active — it is the single biggest determinant of whether the active ever reaches its target. The skin is built to keep things out, and its outermost layer, the stratum corneum, is a...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Vitamin C has an absorption ceiling that most prescribing conversations ignore. Uptake from the gut runs through a saturable sodium-dependent transporter (SVCT1), so once a patient is at steady state, plain oral doses above roughly 500 mg a day are...
by Darren ng | Aug 3, 2026 | Supplements
Short answer: Inositol — most often the pairing of myo-inositol and D-chiro-inositol — is one of the most commonly discussed supplements in polycystic ovary syndrome (PCOS) and insulin-resistance care, usually cited in a 40:1 myo-to-D-chiro ratio at around 4 g of...
